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    Characterization of Small Molecule Binding; Use of Labels Not Required

    Woburn, Massachusetts, September 28, 2006 -- SRU Biosystems, Inc. announced today that the Company was recognized at this year's Annual Meeting of the Society for Biomolecular Sciences (SBS 2006) with one of the conference's Best Poster awards. SRU development scientists, in collaboration with researchers at GlaxoSmithKline's Pharmaceutical Drug Discovery Center in Tres Cantos, Spain, presented a poster entitled, BIND Microplate Label-free Biosensor Applied to Screening and Characterization of Small Molecule Ligands to Multiple Proteins.

    The work shows how BIND can be used to measure direct binding of small molecules to immobilized protein targets without labels. The latest results utilized a validation library of greater than 1,400 diverse compounds to evaluate the use of the BIND Reader and 384-well BIND Biosensor plates to characterize a variety of small molecule-ligand interactions,î explained Lance Laing, PhD, who directed the research for SRU. Two important aspects of the work included the ability to measure active protein in the presence of DMSO and to characterize small molecule binding for specificity, affinity and mechanism of action.

    Owen Dempsey, CEO of SRU Biosystems, stated, "We at SRU wish to thank the Society for Biomolecular Sciences for recognizing the importance of our work with GSK." Mr. Dempsey continued, "SRU's intellectual property portfolio encompasses all aspects of the BIND System, which we believe sets the standards in label-free detection. We want to focus on commercializing the BIND product line. From proteins to small molecules and cells; from 96-well biosensor plates for antibody affinity ranking to small molecule drug development in 384-well biosensor plates, BIND is an exciting tool in the hands of our customers.