Takhmina Ayupova

Department of Bioengineering


Bachelor of Engineering in Electronic Engineering and Nanotechnology, University of York (UK), 2013

Master of Science in Nanotechnology and Regenerative Medicine, University College London (UK), 2017

Research Interests

I am interested in devising and optimizing surface functionalization methodologies and nanomaterials for analysis of interactions at the micro nano scale level. My current research project involves the use of Photonic Resonator Absorption Microscopy for the detection of miRNA associated with prostate cancer, breast cancer, maternal health, and nutrition. 

Research Experience 

Laboratory of Biosensors and Bioinstruments, Nazarbayev University, Nur-Sultan, Kazakhstan

Consultant, January 2021- August 2022; Researcher, April 2014 – December 2020

  • Fabrication and functionalization of optical fiber sensors;
  • Biofunctionalisation of quartz crystal, fabrication of microfluidic flow-cell;
  • Development of an aptasensor for the detection of breast cancer stem cells. 

Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan 

Junior Researcher, October 2013 – April 2014

  • DNA extraction from the blood (kit), PCR, electrophoresis, endonuclease digestion. 


1. Leitão C., Pereira S.O., Marques C., Cennamo N., Zeni L, Shaimerdenova M., Ayupova T., Tosi D. Cost-Effective Fiber Optic Solutions for Biosensing. Biosensors.

2. Tosi D., Shaimerdenova M., Sypabekova M., Ayupova T. Minimalistic design and rapid-fabrication single-mode fiber biosensors: Review and perspectives. Optical Fiber Technology.  (2022).

3. Bekmurzayeva A., Ashikbayeva Z., Assylbekova N., Myrkhiyeva Z., Dauletova A., Ayupova T., Shaimerdenova M., Tosi D. Ultra-wide, attomolar-level limit detection of CD44 biomarker with a silanized optical fiber biosensor. Biosensors and Bioelectronics. (2022)

4. Shaimerdenova M., Ayupova T., Ashikbayeva Z., Bekmurzayeva A., Blanc W., Tosi D. Reflector-Less Shallow-Tapered Optical Fiber Biosensors for Rapid Detection of Cancer Biomarkers. Journal of Lightwave Technology. (2022) – Article in press

5. Bekmurzayeva, A., Ashikbayeva Zh., Myrkhiyeva Zh., Nugmanova A., Shaimerdenova, M., Ayupova T., Tosi D. Label-free fiber-optic spherical tip biosensor to enable picomolar-level detection of CD44 protein. Scientific Reports. (2021)  

6. Tosi D., Ashikbayeva Zh., Bekmurzayeva, A., Myrkhiyeva Zh., Rakhimbekova A., Ayupova T., Shaimerdenova, M. Optical fiber ball resonator sensor spectral interrogation through undersampled KLT: application to refractive index sensing and cancer biomarker biosensing. Sensors. (2021) 

7. Ayupova, T., Shaimerdenova, M., Sypabekova, M., Vangelista, L., Tosi D. Picomolar detection of thrombin with fiber-optic ball resonator sensor using optical backscatter reflectometry. Optik. (2021) 

8. Shaimerdenova, M., Ayupova, T., Nugmanova, A., Dauletova, A., Tosi D. Polarization-sensitive optical fiber-tip ball resonators for refractive index sensing with optical backscatter reflectometer interrogator. Optical Fiber Technology. (2021) 

9. Ayupova, T., Shaimerdenova, M., Tosi D. Shallow-tapered chirped fiber Bragg grating sensors for dual refractive index and temperature sensing. Sensors. (2021) 

10. Shaimerdenova M., Ayupova T., Sypabekova M., Tosi D. Thrombin Detection on Ball Resonator Using Optical Backscatter Reflectometry. 2021 Conference on Lasers and Electro-Optics, CLEO 2021 – Proceedings. (2021)

11. Shaimerdenova M., Ayupova T., Sypabekova M., Tosi D. Thrombin detection on ball resonator using optical backscatter reflectometry. Optics InfoBase Conference Papers. (2021)

12. Ayupova, T., Shaimerdenova, M., Bekmurzayeva, A., Sypabekova M., Aitkulov, A., Tosi D. Detection of thrombin protein with ball lens microresonator fabricated using CO2 laser splicing system. Progress in Biomedical Optics and Imaging – Proceedings of SPIE. (2021)

13. Shaimerdenova, M., Ayupova, T., Sypabekova, M., Tosi, D. Fiber optic refractive index sensors based on a ball resonator and optical backscatter interrogation. Sensors (Switzerland). (2020). 

14. Ayupova, T., Tosi, D., Shaimerdenova, M., Guo, T., Molardi, C. Fiber optic refractive index distributed multi-sensors by scattering-level multiplexing with MgO nanoparticle-doped fibers. IEEE Sensors Journal. (2020). 

15. Ayupova T., Shaimerdenova M., Korganbayev S., Sypabekova M., Bekmurzayeva A., Blanc W., Molardi C., Tosi D. Fiber Taper Refractive Index Sensor detection by Optical Backscatter Reflectometer. Photonics West (BIOS) San Francisco, United States. Feb 2020.

16. Shaimerdenova, M., Bekmurzayeva, A., Ayupova, T. Molardi, C., Tosi, D. Spatial multiplexing of refractive index distributed sensors by means of high-scattering MgO nanoparticle doped optical fiber. Progress in Biomedical Optics and Imaging – Proceedings of SPIE. (2020). 

17. Sypabekova, M., Korganbayev, S., González-Vila, Á., Ayupova, T., Vangelista, L., Tosi, D. Functionalized etched tilted fiber Bragg grating aptasensor for label-free protein detection. Biosensors and Bioelectronics. (2019). 

18. Korganbayev, S., Shaimerdenova, M., Ayupova, T., Molardi, C., Tosi, D. Refractive index sensor by interrogation of etched MgO nanoparticle-doped optical fiber signature. IEEE Photonics Technology Letters. (2019). 

19. Korganbayev, S., Bekmurzayeva, A., Shaimerdenova, M., Ayupova, T., Sypabekova, M., Tosi, D. Compact fiber optic sensors for dual temperature and refractive index profiling based on partially etched chirped fiber Bragg grating. Proceedings of IEEE Sensors. (2018). 

20. Sypabekova, M., Korganbayev, S., Blanc, W., Ayupova, T., Molardi, C., Tosi, D. Fiber optic refractive index sensors through spectral detection of Rayleigh backscattering in a chemically etched MgO-based nanoparticle-doped fiber. Optics Letters. (2018). 

21. Bekmurzayeva, A., Dukenbayev, K., Shaimerdenova, M., Ayupova, T., Molardi, C., Tosi, D. Etched fiber Bragg grating biosensor functionalized with aptamers for detection of thrombin. Sensors. (Switzerland). (2018). 

22. Korganbayev, S., Ayupova, T., Sypabekova, M., Molardi, C., Tosi, D. Partially etched chirped fiber Bragg grating (pecfbg) for joint temperature, thermal profile, and refractive index detection. Optics Express. (2018). 

23. Molardi, C., Ayupova T., Sypabekova, M., A. Bekmurzayeva, A., Shaimerdenova, M., Tosi, D. Wavelet analysis of multi-mode behavior of an etched fiber Bragg grating sensor operating in sucrose solutions. Proceedings of SPIE – The International Society for Optical Engineering. (2018). 

24. Ayupova, T., Sypabekova, M., Molardi, C., Dukenbayev, K., Tosi, D. Wavelet-based demodulation of multimode etched fiber Bragg grating refractive index sensor. Sensors. (Switzerland). (2018). 

25. Shaimerdenova, M., Bekmurzayeva, A., Ayupova, T., Molardi, C., Tosi, D. Detection of various thrombin concentrations using etched fiber Bragg gratings functionalized with DNA aptamer. Proceedings of SPIE – The International Society for Optical Engineering. (2018). 

26. Shaimerdenova, M., Ayupova T., Sypabekova, M., Korganbayev, S., Bekmurzayeva, A., Dukenbayev, K., Molardi, C., Tosi, D. An etched chirped fiber Bragg grating for measurement of refractive index and temperature pattern. Proceedings of SPIE – The International Society for Optical Engineering. (2018). 

Honors and Awards

  • MSc in Nanotechnology and Regenerative Medicine with Merit, UK; 2017
  • BEng in Electronic Engineering with Honors, UK; 2013
  • “Talap” Scholarship, Nazarbayev University, Kazakhstan (funding of MSc degree at UCL); 2016
  • Scholarship, Pipers Corner School, UK (funding of A-Level); 2010
  • Duke of Edinburgh Silver Medal of International Class (The world’s leading youth achievement award), UK; 2010